It's 1926 and reapers, the once-human vampires with a terrifying affliction, are on the rise in New York. But the Saint family's thriving reaper-hunting enterprise holds reign over the city, giving them more power than even the organized criminals who run the nightclubs. Eighteen year-old Elise Saint, home after five years in Paris, is the reluctant heir to the empire. Only one thing weighs heavier on Elise's mind than her family obligations: the knowledge that the Harlem reapers want her dead. Layla Quinn is a young reaper haunted by her past. Though reapers have existed in America for three centuries, created by New World atrocities and cruel experiments, Layla became one just five years ago. The night she was turned, she lost her parents, the protection of the Saints, and her humanity, and she'll never forget how Elise Saint betrayed her. But some reapers are inexplicably turning part human again, leaving a wake of mysterious and brutal killings. When Layla is framed for one of these attacks, the Saint patriarch offers her a deal she can't refuse: to work with Elise to investigate how these murders might be linked to shocking rumors of a reaper cure. Once close friends, now bitter enemies, Elise and Layla explore the city's underworld, confronting their intense feelings for one another and uncovering the sinister truths about a growing threat to reapers and humans alike.